EPUB · MOBI The Family Gene ô 9780062378897 FREE ã JOSELIN LINDER

TEXT â The Family Gene Ø Joselin Linder

Led a private mutation meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation Here Joselin tells the story of their gene the lives it claimed and the future of genomic medicine with the potential to save those that remain Digging into family records and medical history conducting interviews with relatives and friends and reflecting on her own experiences with the Harvard doctor Joselin pieces together the lineage of this deadly gene to write an exploration of family history and love I was pulling into the parking lot of the supermarket where I shop listening to NPR The interview with Ms Linder that was so fascinating so interesting I sat in the parking lot until the interview ended And I promptly ordered the book I have a potentially fatal genetic disorder but at 72 I do not give it much thought I know of no one in my family history who had it But could it have been properly diagnosed?Is my case a one off a one time thing? Am I the first documented case in my family? Will any of my descendants develop it?Ms Linder's account did not and cannot address mine but it helped me understand I must say Ms Linder has a wonderful gift for making complex scientific medical and genetic terms comprehensible to this lay personMy only reluctance to grant five stars is my disinterest in her personal Sturm und Drang during adolescence

KINDLE The Family Gene

The Family GeneA riveting medical mystery about a young woman’s uest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicineWhen Joselin Linder was in her twenties her legs suddenly started to swell After years of misdiagnoses doctors discovered a deadly blockage in her liver Struggling to find  an explanation for her unusual condition Joselin compared the medical chart of her father who had died from a mysterious disease ten years prior with that of an uncle who had died under simila 35 My eye was drawn to The Family Gene because of the medical mystery aspect 14 members of Linder’s Ashkenazi Jewish family are the only known exemplars of their particular genetic disease so rare it doesn’t have a name or surefire treatment protocol but now at least has a location on a chromosomeLinder’s awareness of her family’s peculiar medical problems began when her father William himself a doctor near their home in Columbus Ohio started having a persistent build up of lymph also known as chyle in his abdomen – usually a sign of heart or liver failure At one point doctors tapped four liters of the stuff from his lungs Her father’s illness threw Linder then a junior in college for a loop; drugs and music started to replace academics After he died aged 49 in September 1996 she became a nomad moving from Prague to San Francisco to Brooklyn and dabbling in different careersOnly gradually did they all realize that the same thing had happened to William’s uncle Nathan in the 1960s and his grandmother Mae before that While Mae lived to age 54 Nathan died at 34 even after treatment at NIH Along with the lymphedema a heart murmur was a common factor William’s brother Norman; Linder and her older sister Hilary; and various cousins of their generation were diagnosed in this way The author’s own symptoms were initially easily to ignore – swollen ankles and a low platelet count – but escalated in her thirties a blocked vein in her liver meant she was in danger of bleeding out if she vomitedIt’s rare to be able to trace a genetic disease from its founder through to the present In Linder’s case her great great grandmother Ester Bloom is the first known sufferer Researchers eventually isolated their family’s gene on the X chromosome near the location for asthma This explained why historically female family members had a better prognosis than males – they have one normal X chromosome and one diseased one; men only get the defective X chromosome – and why asthma medication helped to an extentThere are a couple of chapters here on the basics of genetics that felt a little condescending to me; for anyone with a high school or A level biology ualification the simplistic metaphors explaining the workings of DNA may seem superfluous I also had trouble relating to Linder’s immediate reaction to her father’s death Although he’d been severely ill for years by then her attitude still seems a little heartless Of the decision to take him off dialysis she writes “I was on board It was time to call it a day” When the family went around expressing opinions she said “I think it’s time Dad You’ve been through so much” to which he replied “F— you” An ex boyfriend’s suicide a couple years later affected her much than her own father’s death Grief affects people in strange and unpredictable ways I guessWhat I most appreciated was how the book sensitively reveals the ways a genetic condition complicates life especially in America Linder had to do without health insurance for 10 years having been denied it in Ohio on the grounds of a pre existing condition In addition she and her sister faced a uandary common to those who carry genetic diseases should they have children? While Hilary underwent pre implantation genetic diagnosis a form of IVF to bear healthy twins Linder ultimately decided against having childrenI enjoyed the earlier part of this genetic uest narrative a bit than the later material about Linder’s symptoms Still I can recommend this to viewers of House and readers of Susannah Cahalan’s Brain on Fire and the likeOriginally published on my blog Bookish Beck

Joselin Linder Ø The Family Gene TEXT

EPUB · MOBI The Family Gene ô 9780062378897 FREE ã JOSELIN LINDER Ö [KINDLE] ✽ The Family Gene ❁ Joselin Linder – Gwairsoft.co.uk A riveting medical mystery about a young woman’s uest to uncover the truth about her likely fatal genetic disorder that opens a window onto tRly strange circumstances Delving further into the past she discovered that her great grandmother had displayed symptoms similar to hers before her death Clearly this was than a fluke Setting out to build a complete picture of the illness that haunted her family Joselin approached Dr Christine Seidman the head of a group of world class genetic researchers at Harvard Medical School for help Dr Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something cal This review and others can be found on BW Book ReviewsThis book took me a long time to listen to because it was interrupted by my finals No work means no listening to books Even though it was good I couldn't listen to it on my free time thanks to being a responsible college student and doing this dreadful thing called studying Warn your kids about it It can get pretty terrifyingAs I said this was a good book It was fun and I really enjoyed how it was read Just very upbeat and light most of the time When this book focuses on a family illness that is currently untreatable and has killed everyone who has it the author's father uncle and other people that's really impressive It's a very light book It's fun to read or listen to because it simply flows so wellStarting in the 90s this book chronicles a family illness It begins with Joselin's father a doctor who gets ill Very ill I think ill is an understatement to it Then as he gets worse then it comes out that other people in his family had the same symptoms that he does They also died of this mystery disease They don't know what it is but know that everyone who has had it has a heart murmur testing people in the family for itAt times it was heavy with technical terms but Joselin explained them perfectly I've taken enough classes and read enough books to know most of the terms She just told it what it is in non doctor speak It's accessible to anyone really All you have to know is the basics and anything beyond it she explains Hell even the basics get explainedIt largely focuses on Joselin's experiences She's not a doctor after all She's a woman who watched various members of her family get sick and die It's focused on her experience of this and the stages of grief that she went through While I'm not sure I would have liked Joselin as a person for a good part of the story I could appreciate it She reacted in a way people only can Still hearing about her healing process didn't uite interest me as much as hearing the journey of discovery about their disorderAll in all a good book that had very minor flaws for me